August 13, 2021 | 7:00 PM (Pre-Season Scrimmage)
Cuyahoga Heights 14 — Cleveland Central Catholic 12 (Cleveland, Ohio)
Cuyahoga Heights High School Stadium
August 20, 2021 | 7:00 PM (Home Game)
Cuyahoga Heights 38 — Berkshire 35 (Burton, Ohio)
Cuyahoga Heights High School Stadium
August 27, 2021 | 7:00 PM (Home Game) Canceled
Cuyahoga Heights — Brookside (Sheffield, Ohio)
Cuyahoga Heights High School Stadium
September 4, 2021 | 12:00 PM
Cuyahoga Heights 35 — John Marshall 6 (Cleveland, Ohio)
John Marshall High School Stadium
September 10, 2021 | 7:00 PM (Home Game)
Cuyahoga Heights 28 — Independence 30 (Independence, Ohio)
Cuyahoga Heights High School Stadium
Conference Game
September 17, 2021 | 7:00 PM
Cuyahoga Heights 35 — Trinity 6 (Garfield Heights, Ohio)
Trinity High School Stadium
Conference Game
October 1, 2021 | 7:00 PM (Home Game)
Cuyahoga Heights — Brooklyn (Brooklyn, Ohio)
Cuyahoga Heights High School Stadium
Conference Game
October 8, 2021 | 7:00 PM
Cuyahoga Heights — Lutheran West (Rocky River, Ohio)
Lutheran West High School Stadium
Conference Game
October 15, 2021 | 7:00 PM
Cuyahoga Heights — Cardinal (Middlefield, Ohio)
Cardinal High School Stadium
October 22, 2021 | 7:00 PM (Home Game)
Cuyahoga Heights — Wickliffe (Wickliffe, Ohio)
Cuyahoga Heights High School Stadium
Conference Game